| Restoration Process of Blood Circulation after Hemorrhage and Hemostasis |
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| 1. Hemorrhage (Bleeding) |
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| Blood vessel gets injured by some foreign matter, thick blood or pressure, and starts bleeding. |
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| 2. Hemostasis (White Thrombus) |
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| Thrombocytes (blood platelets) and fibrinogens gather around the injured part, and work together to stop the bleeding. |
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| 3. Coagulation (Red Thrombus) |
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| After Hemostasis, fibrinogens in the blood are turned into fibrins by the effect of thrombin. Fibrin promotes hemostasis, and treats the bleeding part. |
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| 4. Restoration |
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| The vessel wall cells are multiplied and restored using fibrins as their footfold. |
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Lumbrokinase does not only dissolve fibrin itself directly as plasmin does, but does it also work to increase the amount of plasminogen activators (such as t-PA) in the blood stream.
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| 5. Fibrinolysis |
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As soon as a fibrin mass is built, plasminogen in the blood are activated by plasminogen activators (t-PA & u-PA) supplied from the endothelial cells.
Plasmin dissolves fibrin mass and breaks it down into FDP.
t-PA: tissue plasminogen Activator
u-PA: urokinase Plasminogen Activator
FDP: Fibrin Degradation Products |
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| 6. Circulation normalized |
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Those with regular lumbrokinase administration are reported to have about 10 times more inactive t-PA than those without it.
When excess fibrins appear in their vessels, inactive t-PA are activated, and immediately dissolve the fibrins. |
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